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KMID : 1149220010090010375
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Korean Journal of Oriental Medical Prescription
2001 Volume.9 No. 1 p.375 ~ p.385
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The Effects of Sagunja-tang on Liver Injury of Mice Induced by CCl4
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Kim Young-Gyun
Cho Su-In
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Abstract
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Objectives : This study was carried out to research the protective effects of Sagunja-Tang(SA) through in vivo experiments, and tried to investigate the relation between oxidation of liver tissues and deficiency of Qi.
Methods : Acute liver injury which initiated from free radical induced by CCl4 were applied to mice and metabolic data were obtained. In order to measure the degree of liver injury, serum level of alanine aminotransferase(AST), aspartate aminotransferase(ALT), creatinine, blood urea nitrogen(BUN), total protein(TP) and glucose were measured. Lipid peroxidation of liver slice was examined by measuring malondialdehyde(MDA), a product of lipid peroxidation.
Results : SA had protective effects on CCl4 induced acute liver injury by decreasing serum level of ALT. Kidney injury was induced by injection of CCl4 too, and SA protected kidney injury by decreasing serum level of creatinine and BUN.
Conclusions : Through this study, we found that SA have healing effects on liver and kidney injury of CCl4 induced oxidative stress that is similar to deficiency of Qi. And further studies have to be followed to certify the mechanisms.
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KEYWORD
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Sagunja-tang, CCl4, liver injury, oxidation, AST, ALT
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